Serum sialic acid and its lipid and protein bounds as possible biomarkers of acute myocardial infarction in Erbil city

Myocardial infarction [MI] usually occurs when coronary blood flow decreases abruptly after a thrombotic occlusion of a coronary artery previously affected by atherosclerosis. Sialic acid [SA] is attached to non reducing residues of the carbohydrate chains of glycoproteins and glycolipids. An elevation in serum TSA, LBSA and PBSA concentrations has been observed in a number of pathological conditions .The aim of the study was to determine the serum TSA and its LBSA and PBSA in patients with acute myocardial infarction [AMI]. Serum TSA, LBSA and PBSA concentrations were evaluated by UV/VIS spectrophotometry in [100] apparently healthy individuals and [100] newly diagnosed AMI patients. The mean levels of serum TSA, LBSA and PBSA in AMI patients were significantly higher [P<0.05] than those of apparently healthy individuals. The results indicate that the serum values of TSA, LBSA and PBSA appeared to be of a value in diagnosis of AMI

Inhibitory effects of some substrate level analogues on salp-activity in B-thalassaemia

Higher levels of SALP-activity was recorded in serum of patients with a-thalassaemia in comparison with normal control Subjects at specific PH and temp. Both kinetic constant, Km and Vmax has been determined. Inhibitory effects of three substrate analogues, L-Phe, Adenosine, and inorganic phosphate were investigated. Types and degree of inhibition were determined together with values of Ki [inhibitory constant] using Dixons plot